SCH-50911 is a selective GABAB antagonist developed by Schering-Plough Corporation. Its main applications are in pharmacology research, but it has been found to quickly and effectively reverse the symptoms of GHB overdose in mice. In one experiment, mice were given a lethal dose of GHB (7000mg/kg) followed by varying doses of SCH-50911. At the two higher doses of the antagonist (150mg/kg and 300mg/kg), only 2 out of 20 of the mice died (10%), compared to 100% lethality in the control group. SCH-50911 also acts as an anticonvulsant under normal conditions, and so counteracts both the depressant and pro-convulsant effects of GHB overdose. This pharmacological profile makes SCH-50911 a promising candidate as a GHB antidote for human use, and might also make it useful for treating overdoses of other GABAB agonists such as Baclofen. SCH-50911 has never been tested for this purpose in humans and there are no plans at this stage to develop it for these applications. However SCH-50911 induces acute withdrawal syndrome in GHB-dependent rats, similar to the delirium tremens seen in human alcohol withdrawal, and can precipitate convulsions in GHB-dependent animals. This means that while SCH-50911 is likely to be a useful antidote for GHB overdose in non-addicted individuals, its use in people who are dependent on GHB or its analogues could be potentially dangerous as it might precipitate acute withdrawal symptoms, and additional anticonvulsants such as diazepam would most likely be required to counteract the risk of life-threatening seizures. This is similar to the problems seen with opioid antagonists such as naloxone, which are useful antidotes to opiate overdose but may precipitate acute withdrawal syndrome in opiate-addicted individuals. File:FlattenedRoundPills. jpg This pharmacology-related article is a stub. You can help Wikipedia by expanding it. v o d o e
Also try this free pdf e-books:
Correllian Times Emagazine - Issue 35 July 2009
Aleister Crowley - Liber 011 Nu
Labels: medieval manuscripts collection quests alchemy introduction alchemy tablet isaac circa secret mary list great poetry philosophicum alchemical ritual mind focus aries and sagittarius temple contacting extraterrestrial heathen faith questions
